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200 employees
Evry-Courcouronnes, France (91)
Aligned with INSERM (about 2621 euros monthly gross salary, adapted to professional experience on equivalent positions)
February 15, 2022

Postdoctoral position for hematopoietic stem cell based gene therapy

Job description

The Therapeutic Genome Editing research group directed by Mario Amendola in the INTEGRARE unit ("integrated genetic approaches for the treatment of rare genetic diseases", also identified as UMR_S951) of Genethon focuses on developing effective and safe genome editing and gene therapy strategies for the treatment of human diseases. In particular, we are interested in genetically engineering hematopoietic stem and progenitor cells: 1) for treating and gaining a better understanding of blood disorders, in particular hemoglobinopathies and hemophilia; 2) as therapeutic delivery vehicles for metabolic diseases, due to the ability of their progeny to extensively home to many tissues, including the central nervous system (https://integrare-umrs951.jimdo.com/home/labs/gene-editing/).

Genethon Institute is a non-profit biotherapy R&D organization dedicated to the development of gene therapy products for rare human genetic diseases (www.genethon.com). Genethon hosts several laboratories exploiting gene-based technologies to investigate biological systems and pathologies of genetic origin and to design gene therapy treatments mainly for: i) blood and immune disorders, ii) neuromuscular disorders, iii) liver and metabolic disorders.
Genethon offers several high quality core facilities and infrastructure including:
 in vitro and in vivo therapeutic testing platform: a functional evaluation platform (including
ultrasound testing), an imaging-cytometry platform (confocal, macro confocal and biophotonic microscopy, imaging flow cytometry), a viral vector research facility (for LV, RV and AAV), tools and experience in molecular and physiopathological examination of isolated living cells; a histology department,
 the largest DNA and cell bank in Europe for human genetic disorders.

The Genethon Institute is located in the Genopole Campus, a France's leading biocluster located in Evry-Courcouronnes, France (91).
Genethon is an equal opportunity employer and supports gender equality.

Desired profile

We are currently seeking a highly motivated and talented postdoc to join our group working on the use of CRISPR and viral vectors to develop novel gene therapy technologies and approaches. If you like responsibilities and want to take part of this wonderful adventure with a team built with deep expertise in gene therapy development, this job is for you!

First and foremost, the desire to make an impact in the field of Gene Therapy in a friendly, enthusiastic, dedicated and collaborative manner.
Candidates should be able to work independently and interactively in a team setting, be responsible, organized and have a great work capacity and enthusiasm for research and smiling and positive attitude.
If you are strongly interested in this position but do not meet one or more criteria, please address in your cover letter in which aspects your skill set deviates from the outlined profile as well as how your background would enrich our research.

If your profile matches the description, please send:
 motivation letter
 CV
 contact details of two referees
 ideal starting date
Documents should be sent as a single pdf file by email to mamendola@genethon.fr.
If you are strongly interested in this position but do not meet one or more criteria, please address in your cover letter in which aspects your skill set deviates from the outlined profile. For further information, please directly contact mamendola@genethon.fr.

Fixed-term contract of 2 years, starting no later than October 1st, 2022.